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KMID : 0358319950360010023
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Korean Journal of Urology
1995 Volume.36 No. 1 p.23 ~ p.27
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Alteration of Nerve Growth Factor in the Penis of Rats with Streptozotocin-induced Diabetes
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조진선
류 인/김경안/이상곤/박영의
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Abstract
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Insulin and nerve growth factor (NGF) share sefveral properties concerning physiological activity, molecular structure and site of synthesis. Considering the properties that NGF shares with insalin, and the important role it plays on nerve
physiology,
NGF may participate in the pathophysiology of diabetic neuropathy.
We investigated the alterations of NGF in the penis of diabetic rats at 8-week after induction of diabetes with streptozotocin. NGF was determined by sandwich ELISA method. The weight gain reduced significantly in diabetic rats. Diabetic rats
showed a
significantly reduced NGF content in the penis (62.3% of control, p<0.05 at 8-week after induction of diabetes.
These findings suggest that decreased NGF levels in the penis of diabetic rats may be invoved in the develpment of the diabetic neuropathy regarded as important cause of diabetic importence.
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KEYWORD
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